Roles of antibodies to influenza A virus hemagglutinin, neuraminidase, and M2e in conferring cross protection
نویسندگان
چکیده
منابع مشابه
Long-Lasting Cross-Protection Against Influenza A by Neuraminidase and M2e-based immunization strategies
There is mounting evidence that in the absence of neutralizing antibodies cross-reactive T cells provide protection against pandemic influenza viruses. Here, we compared protection and CD8+ T cell responses following challenge with H1N1 2009 pandemic and H3N2 viruses of mice that had been immunized with hemagglutinin (HA), neuraminidase (NA) and the extracellular domain of matrix protein 2 (M2e...
متن کاملInfluenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape.
The cytoplasmic tails of the influenza virus glycoproteins hemagglutinin (HA) and neuraminidase (NA) are highly conserved in sequence for all virus subtypes and it is believed that assembly of this enveloped virus depends on interactions of these domains with cytoplasmic viral components. However, it is possible to rescue altered influenza viruses lacking either the HA or NA cytoplasmic tails. ...
متن کاملA novel neuraminidase deletion mutation conferring resistance to oseltamivir in clinical influenza A/H3N2 virus.
Neuraminidase (NA) mutations responsible for influenza resistance to oseltamivir vary according to the NA subtype; in influenza A/H3N2 viruses, NA-gene mutations occur predominantly at codons E119 and R292. In an oseltamivir-resistant influenza A/H3N2 virus isolated from an immunocompromised child after 107 days of cumulative treatment, the NA gene contained 3 aa substitutions (N146K, S219T, an...
متن کاملMechanisms of Cross-protection by Influenza Virus M2-based Vaccines
Current influenza virus vaccines are based on strain-specific surface glycoprotein hemagglutinin (HA) antigens and effective only when the predicted vaccine strains and circulating viruses are well-matched. The current strategy of influenza vaccination does not prevent the pandemic outbreaks and protection efficacy is reduced or ineffective if mutant strains emerge. It is of high priority to de...
متن کاملNeuraminidase Antibodies and H5N1: Geographic-Dependent Influenza Epidemiology Could Determine Cross-Protection against Emerging Strains
Muin J. Khoury, Julian Little, Julian Higgins, John P. A. Ioannidis, Marta Gwinn We applaud PLoS editors for their commitment to publishing high-quality systematic reviews (SRs) [1]. Moher et al. [2] clearly documented the inconsistent quality of reporting of SRs. With more than 2,500 SRs published every year, low-quality or outdated reviews may mislead researchers, providers, and policy makers...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2017
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2017.09.011